Open Source Python Projects
Discover 596 open source Python repositories from GitHub, each with an analysis of what it does, key features, use cases and alternatives. Python projects here are most often combined with LLM, AI and Machine Learning. Last updated October 3, 2026.
596 repositories · updated October 3, 2026
Meshtastic-MCP: AI Tooling for Meshtastic Device Control and Testing
Meshtastic-MCP provides an MCP server and agent skills designed for AI tooling to discover, drive, observe, and test Meshtastic devices and applications. It offers a comprehensive suite of capabilities, from portable device control to advanced hardware-free end-to-end testing and replay functionalities. This project aims to streamline the development and testing of Meshtastic ecosystems.
Graphon: A Python Graph Execution Engine for Agentic AI Workflows
Graphon is an innovative Python-based graph execution engine designed for building agentic AI workflows. It provides a robust framework for orchestrating complex AI tasks, featuring event-driven execution, graph validation, and shared runtime state. This evolving repository already includes a functional engine, built-in nodes, and end-to-end examples for developers.
text-to-cad: AI Agent Skills for CAD, CAE, and CAM Workflows
text-to-cad is a comprehensive Python library developed by earthtojake, providing a rich set of agent skills for Computer-Aided Design (CAD), Computer-Aided Engineering (CAE), and Computer-Aided Manufacturing (CAM). It enables AI agents to generate, inspect, source, slice, and manage CAD and robot-description artifacts, streamlining complex engineering processes.
dcc-mcp-blender: AI-Driven 3D Workflows with an Embedded MCP Server
dcc-mcp-blender is a powerful Blender addon that integrates an embedded Streamable HTTP MCP server directly into Blender. This allows any MCP-compatible AI client to seamlessly control and automate your 3D modeling, animation, and rendering workflows. It offers over 200 pre-built tools and an extensible skill system for robust production environments.
i-have-adhd: Streamline Your Coding Agent's Output for Clarity
i-have-adhd is a powerful skill designed to transform your coding assistant's responses into clear, actionable, and concise outputs. It prevents AI agents from burying essential information, ensuring you receive direct answers and numbered steps without unnecessary preamble or fluff. This tool is ideal for developers seeking enhanced productivity and straightforward guidance from their AI coding partners.
AutoResearch: AI/ML Research Agents from Idea to Paper-Ready Evidence
AutoResearch is an open-source agent workflow designed for AI and machine learning research. It automates the entire research process, from generating ideas and planning experiments to execution, analysis, and independent evaluation. This project helps researchers produce paper-ready evidence efficiently and with traceable provenance.
HarnessRouter: Unified Interface for AI Agent Harnesses
HarnessRouter Community Edition provides a self-hosted, Apache-2.0 licensed unified interface for various AI agent harnesses like Codex, Claude Code, and Hermes. It allows users to run multiple agents through a single API, offering features such as sessions, streaming, file handling, and cancellation. The project implements the open-standard Unified Harness Protocol (UHP), ensuring users maintain control over their keys and infrastructure.
Guaardvark: Your Self-Hosted AI Studio for Agents, Media, and Code
Guaardvark is a comprehensive, self-hosted AI studio designed for local execution of advanced AI tasks. It integrates coding agents, media generation (video, image, music, voice), and robust RAG capabilities, all running on a single GPU. This platform prioritizes privacy and user control, enabling a full AI workstation experience on your own hardware.
AREX-Skill: A Skill Library for Automated Machine Learning and Auto-Research
AREX-Skill is a powerful skill library designed to advance automated machine learning and auto-research. It distills over 5,000 executable skills from more than 1,000 popular GitHub repositories, making complex ML knowledge directly usable by coding agents. This project significantly enhances agent performance in various research tasks by providing structured, validated operating knowledge.
Maskit: Local Privacy Gateway for LLMs and AI Tools
Maskit is a local privacy desensitization gateway engineered for large language models and AI tools. It automatically masks sensitive data in requests sent to AI services and then seamlessly restores it in streaming responses, ensuring private information remains local. This innovative solution supports various AI assistants like Cursor and Claude Code, along with any tool offering a configurable Base URL.
CyberVerse: Self-Hosted Real-Time Digital Human Agent Platform
CyberVerse is an open-source, self-hosted platform for building real-time digital human agents. It leverages WebRTC, persona memory, tools, and RAG to create voice-first AI agents, with optional digital-human video capabilities. This powerful framework allows developers to create highly interactive and lifelike AI companions.
oh-my-hermes: Enhance Hermes Agent with Advanced AI Workflow and Memory
oh-my-hermes is an all-in-one plugin designed to significantly enhance the Hermes Agent. It provides advanced coding intelligence, a robust long-term memory system, and optimized workflow packages, transforming standard Hermes requests into structured, actionable tasks with clear operational layers.